Virginia Tech's Smart Infrastructure Laboratory (VT-SIL) mission is to advance education and research in topics that utilize sensor information to improve the design, monitoring and daily operation of civil and mechanical infrastructure as well as to investigate how humans interact with the built environment. The centerpiece of VT-SIL will be a full-scale living laboratory in the new, 160,000 square foot, Signature Engineering Building (SEB) on the Virginia Tech campus. In conjunction with the VT College of Engineering, VT-SIL is currently developing and building this living laboratory, where over 140 accelerometer mounts (3 axis per mount capability), along with other sensors, are being mounted throughout the entire building. Upon completion, the SEB will be the most instrumented building for vibrations in the world.